Fibrosis Score Interpretation. 2017 May;66(5):1022-1030** CAP measures the increased attenu

2017 May;66(5):1022-1030** CAP measures the increased attenuation of ultrasound waves when travelling through steatotic hepatic tissue, compared to normal liver. ELF ≥9. Nov 18, 2020 · FIB-4 index helps rule out advanced liver fibrosis in NAFLD using age, AST, platelet count and ALT values with a <1. Dec 1, 2025 · Molecular insights into fibrogenesis and fibrosis regression offer potential targets for antifibrotic therapy and increase the need for noninvasive means to measure changes in fibrosis. Learn what liver stiffness, fat scores, and quality metrics mean for accurately assessing your liver health. Interpretation The FibroTest score (in this case 0. 45 had a negative predictive value of 90% for advanced fibrosis (Ishak fibrosis score 4-6 which includes early bridging fibrosis to cirrhosis). g. Jun 15, 2017 · The FIB-4 score has similar variables as the aspartate transferase to platelet ratio index, with the addition of age. 3 indicates a low risk for significant fibrosis A score of 1. Oct 23, 2018 · The scarring is called fibrosis. Radiograp ic Resonance Elastography of the Liver Quantitative Imag May 6, 2025 · From the Guidelines FibroScan interpretation should be based on the most recent and highest quality evidence, which recommends using a low cutoff of 8. Using your liver stiffness result to find your fibrosis score Your healthcare provider will use your liver stiffness result and medical history to find out your fibrosis score. Fibrosis means scarring of the liver. Bansal adds. 67 (Indeterminate) ELF <9. Advanced Fibrosis (≥F3) AGA recommends using 9. You can find the result interpretation and guidelines on the original study that published the score below the form. When determining your actual fibrosis score, in addition to your fibrosis measurement, your provider will take into consideration your health history and the grade of steatosis. C etic resonance elastography for patient with liver disease in clinical practice. 4 days ago · Interpretation of Results Once calculated, interpret the FIB-4 score using age-adjusted cutoffs 1, 2: FIB-4 <1. Aug 23, 2022 · Doctors use the NAFLD fibrosis score to predict how much scarring there is in the liver. Oct 22, 2025 · How to Read and Interpret a FibroScan FibroScan (transient elastography) is a non-invasive method for assessing liver fibrosis by measuring liver stiffness, with specific cutoff values that reliably identify different stages of fibrosis to guide clinical decision-making. Age is a factor, as the prevalence of NAFLD and its progression to fibrosis tend to increase with advancing years. FIB-4 is the most used, so let’s do a deep dive into its origins… Where did FIB-4 come from? For all testing indications, an elevated FIB-4 index is consistent with the presence of advanced fibrosis, whereas a low FIB-4 index is consistent with the absence of advanced fibrosis. Nov 24, 2025 · Interpret your FibroScan results. Enter the required values to calculate the FIB-4 value. Your results can range from normal to advanced. 45, a FIB-4 score <1. Interpretation FibroTest-ActiTest provides a score that assesses hepatic fibrosis (F0-F4) and a score that assesses hepatic inflammatory activity (A0-A3). Oct 12, 2024 · To deal with health problems from hepatitis C, your doctor can measure the amount of fibrosis in your liver. Your actual fibrosis score (as told by your doctor) may not even match the fibrosis score in the The Enhanced Liver Fibrosis (ELF) Score is a noninvasive test that indicates whether a patient with NASH and advanced fibrosis has a higher or lower risk of disease progression to cirrhosis (for those with F3 fibrosis) or other liver-related clinical events (for those with F3 or F4 fibrosis) within 1 to 4 years. Aug 5, 2025 · Unpack the FIB-4 score to understand its role in assessing liver health and interpreting your results for informed next steps. Sep 6, 2023 · Fibrosis can be reversed if detected early enough and the underlying liver disease that caused the development of fibrosis can be cured or treated. Information for patients This brochure has moved. Jul 27, 2025 · How the Score is Determined The NAFLD Fibrosis Score is calculated using six distinct variables, each offering insights into liver health and potential fibrosis progression. 25 would have a 97% specificity and a positive predictive value of 65% for advanced fibrosis. 0 kPa to indicate likely clinically significant fibrosis. Fibrosis and Cirrhosis scores are further evaluated by an expert system able to detect anomalous profile results and adjust those scores accordingly. 3) Fibrosis Biomarkers Should be measured for patients with NAFLD or HCV and compared to VCTE results determine concordance for presence or absence of advanced fibrosis {FO-F2 vs. 1 Fibrosis scoring systems (FIB-4 and ELF) This page includes information about the ELF and Fib-4 fibrosis scoring systems. Calculate NAFLD (Non-Alcoholic Fatty Liver Disease) Fibrosis Score to assess liver fibrosis risk. This measurement is called a fibrosis score. Mar 22, 2023 · A score of less than 1. 5 High risk for advanced liver fibrosis. While originally developed to detect liver fibrosis among patients with Hepatitis C and HIV, FIB-4 scoring has been increasingly used by the diabetes and NAFLD/NASH communities. Fibrosis develops over time, and eventually can progress into advanced stages. Interpretation Guide Quantifying fibrosis with FibroScan® FibroScan®: medical device which measures liver stiffness (fibrosis) and CAPTM (steatosis) simultaneously on the same volume of tissue (3 cm3). Interpretation: Using a lower cutoff value of 1. The ELF Score is the first noninvasive biomarker blood test for prognostic risk assessment in advanced MASH. 51, then advanced liver fibrosis is unlikely. 6 Finally, the NAFLD fibrosis score includes age, BMI, blood glucose levels We would like to show you a description here but the site won’t allow us. Individual results from the 6 component tests are also provided with institution-specific reference intervals. 455), suggests advanced liver fibrosis. There are several risk scores out you may have heard about such as FIB-4 (Fibrosis-4), APRI (AST to platelet ratio index), and NFS (NAFLD fibrosis score). The CAP score measures the levels of fat in the liver in decibels per meter (dB/m), this score ranges from 100-400 and can fluctuate over time. FIB-4 1. The liver stiffness score directly relates to the degree of fibrosis, or scarring, in the liver. FibroScan “Controlled Attenuation Parameter” (CAP) Interpretation Meta-analysis of 2735 patients comparing histology and CAP with BMI </= 35: Karlas T et al. Nov 9, 2018 · This is a conditional recommendation with low quality of evidence, thus, FibroScan shouldn’t be the only method used to assess fibrosis grade, should be considered in context of other clinical information. Case study Feb 5, 2022 · Can I estimate my Fibrosis Score using my FibroScan fibrosis result? The following table shows liver diseases, ranges of fibrosis results, and the matching fibrosis score. Consider additional assessment for patients with an indeterminant result. To use the table, find the liver disease that you have on the left side of the table. Discover what fibrosis scores mean, what levels are dangerously high, and how to understand your results. The ranges of fibrosis results in the table are estimates. Dec 6, 2025 · FibroScan values should be interpreted using the 2024 WHO-recommended thresholds: >7. In contrast, a FIB-4 >3. The Enhanced Liver Fibrosis (ELF™) blood test is a simple, accurate, non-invasive test that provides a simple, unitless numeric score that is generated via an algorithm for use in advanced liver fibrosis. Mar 30, 2021 · Fibrosis-4 (FIB4) Scoring System for Liver Fibrosis The FIB4 index is an indicator of hepatic fibrosis calculated on the basis of age, aspartate aminotransferase (AST) levels, alanine aminotransferase (ALT) levels, and platelet count, but it does not include variables directly related to liver function. It will appear in the oval on the far right (highlighted in yellow). The NAFLD (Non-Alcoholic Fatty Liver Disease) Fibrosis Score estimates amount of scarring in the liver based on several laboratory tests. Evaluating hepatic fibrosis in chronic hepatitis C patients Diagnosing fibrosis in carriers of chronic hepatitis B virus Evaluating hepatic fibrosis in co-infected HIV carriers Providing access to new-generation non-interferon treatment for hepatitis Evaluating fibrosis in patients suffering from metabolic conditions (nonalcoholic fatty liver AIM: To study whether the severity of liver fibrosis estimated by the nonalcoholic fatty liver disease (NAFLD) fibrosis score can predict all-cause mortality, cardiac complications, and/or liver complications of patients with NAFLD over long-term The NAFLD fibrosis score is used to distinguish between patients with nonalcoholic fatty liver disease who have (F3-F4) and do not have (F0-F2) advanced fibrosis. 0 if age ≥65 years) effectively rule out advan Jan 16, 2023 · The highest possible result is 75 kPa. resonance elastography of liver: techni r fibrosis: a systematic review and meta-analysis of ividual participant data. This topic will review the use of ultrasound-based elastography for assessing liver fibrosis. Jan 11, 2024 · Transient elastography estimates liver fibrosis and steatosis non-invasively using liver stiffness measurement, aiding prognosis and treatment decisions. Recommend referral to Metabolic Hepatology Clinic. Fibrosis score F3: Severe liver scarring Fibrosis score F4: Advanced liver scarring (cirrhosis) Using your FibroScan fibrosis result to estimate your fibrosis score The table below shows liver diseases, ranges of fibrosis results, and the matching fibrosis score. Jun 7, 2023 · FibroScan for assessing liver fibrosis and cirrhosis outside secondary and specialist care Diagnostics guidance DG48 Published: 07 June 2023 We would like to show you a description here but the site won’t allow us. Table. FIB-4 >2. To use ReachDeck to listen to or translate this site you must allow ReachDeck cookies For more information please visit our cookies page Your Fibroscan results explained Your "Liver Fat" score This is the Blue number on the scan – you will hear the medical community referring to it as the CAP score. This NAFLD fibrosis score calculator determines the degree of hepatic fibrosis in patients with non-alcoholic fatty liver disease. Treat metabolic risk factors and if there is ongoing risk suggest repeating test in 3 years. 45 rule-out threshold. It is a stage of long-term liver disease. Using your liver stiffness result to find your fibrosis score 3/8 Using your liver stiffness result to find your fibrosis score Your healthcare provider will use your liver stiffness result and medical history to find out your fibrosis score. Fibrosis (FIB)-4 Score (FIB-4) — a score of greater than 2. Therefore, interpretation of the results is best performed in conjunction with other clinical and/or biochemical parameters, and ideally by someone experienced in managing chronic liver disease. This NAFLD fibrosis score calculator stratifies the degree of fibrosis to the liver in nonalcoholic fatty liver disease patients by assigning a specific stage. G. 0 has an estimated sensitivity of 61 to 76% and specificity of 64 to 72% for detection of severe fibrosis/cirrhosis (F3 to F4 by Metavir). Nov 16, 2025 · FIB-4 has only moderate positive predictive value for confirming advanced disease, meaning a high score does not definitively diagnose advanced fibrosis—it indicates the need for confirmatory testing. Jan 7, 2026 · A score less than 1. This fibrosis 4 (FIB4) score calculator evaluates liver fibrosis based on age, platelet count, AST and ALT to help with cirrhosis diagnosis. The bottom line? NAFLD Fibrosis Score (NFS) — an intermediate or high score (greater than minus 1. 3 (or <2. An ELF Score ≥10. Clear, human conversation about fibrosis scores and liver health. 3 - 2. , FibroScan) and other blood-based tests, Dr. 3 may be considered low-risk, while a Fib4 score of more than 3. The score has been developed for patients between 35 and 65 years of age. Interpretation of the score is provided in the report. But if the damage continues it can cause cirrhosis. FibroScan (TE) in Hepatitis C When the elastography and FibroTest (e. The Fibrosis-4 (FIB-4) score is a non-invasive blood test used to assess the degree of liver fibrosis in patients with chronic liver disease, such as hepatitis C virus (HCV) or non-alcoholic fatty liver disease (NAFLD). 67 High risk for advanced liver fibrosis. F3-F4). This fibrosis 4 (FIB4) score calculator reveals whether there is significant liver fibrosis of different stages associated to cirrhosis using patient age, AST & ALT. For detection of cirrhosis, a cutoff score of at least 2. Results are grouped into low, indeterminate, or high risk for advanced fibrosis. Understanding the FibroScan score is crucial for health professionals, especially in the context of liver diseases like hepatitis and cirrhosis. Test selection and interpretation, diagnosis, and patient management decisions should be based on the physician’s education, clinical expertise, and assessment of the patient. The ELF Score can help identify patients with advanced fibrosis (F3 or F4) at risk of progressing to cirrhosis and liver-related events (LREs). Apr 30, 2024 · Ultrasound-based elastography provides noninvasive approaches for assessing hepatic fibrosis. This allows the identification of advanced liver fibrosis without the need for a liver biopsy. Learn when it's used, how the score is calculated, and how to interpret results. This score represents a shift away from traditional methods, which can be invasive and uncomfortable for patients. Results should be interpreted in conjunction with the patient’s clinical history; particularly when the expert system has adjusted the scores. The utility of the ELF score has been demonstrated primarily in Western countries, but whether it is useful in areas The interpretation of the readings may vary to some degree depending on the liver disease aetiology. 5 (±1) to rule out advanced fibrosis/cirrhosis (13 studies, 4106 patients) Dec 16, 2024 · How to Interpret FibroScan Results The FibroScan test produces two kinds of scores: the controlled attenuation parameter (CAP) score and the fibrosis score. Apart from the FIB-4 or APRI score, we use plenty of different fibrosis scores to asses the probability of the liver disease, with varying levels of invasivity. Free online tool for medical professionals. Patient characteristics and clinical features should guide interpretation. 5 Low risk for advanced liver fibrosis. The information below describes the FibroScan results in more detail, including how your doctor uses your results to determine your steatosis grade and fibrosis score. 1, 2 This is why the two-tier approach (FIB-4 followed by elastography for indeterminate/high scores) maximizes diagnostic accuracy while Nov 7, 2025 · Learn how the FIB-4 Index uses AST, ALT, platelets, and age to estimate liver fibrosis risk—plus how to self-calculate without charges. As per the locally agreed primary care pathway, the ELF test should be considered for the assessment of liver fibrosis in adult patients with NAFLD. The conversion of FibroTest score into stages according to the three most used histological classifications (METAVIR, Knodell and Ishak) for liver biopsies is: FibroTest-ActiTest provides a score that assesses hepatic fibrosis (F0- F4) and a score that assesses hepatic inflammatory activity (A0-A3). 3 or higher suggests you may want further liver assessment There are several follow-up tests available, including measurements of liver stiffness, such as liver elastography (e. Jan 16, 2023 · The highest possible result is 75 kPa. Conventional biochemical and serologic tests, when examined alone, are of little value for the assessment of fibrosis. This test is particularly useful because it is derived from routine blood tests, making it accessible and cost-effective for monitoring liver health. An ideal risk score will be easy to use, cheap, and accurate. Find out more about fibrosis. J Hepatol. The Fibrosis-4 (FIB-4) Index for Liver Fibrosis is a non-invasive scoring system based on several laboratory tests that help to estimate the amount of scarring in the liver. Liver MR Elastography Technique d Image Interpretation: earls and Pitfalls. NAFLD Fibrose Score The NAFLD Fibrosis Score is used to estimate the extent of liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). Mar 16, 2024 · A cutoff score of at least 1. : Fibro Sure, Fibro Test-ActiTest) results agreed, liver biopsy examination confirmed the stage of fibrosis in: 84 percent of cases for F ≥2 fibrosis, 95 percent for F ≥3 fibrosis, and 94 percent for F = 4 fibrosis Reduce the need for liver biopsy by identifying patients with non-alcoholic fatty liver disease likely or unlikely to have advanced fibrosis Using your liver stiffness result to find your fibrosis score Your healthcare provider will use your liver stiffness result and medical history to find out your fibrosis score. If the ELF Score is <10. 88) may indicate the presence of cirrhosis. The NAFLD fibrosis score calculator identifies liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). A liver with fibrosis can still do all its usual jobs. Nov 11, 2025 · The FIB-4 score should be interpreted using age-adjusted cutoffs in a two-threshold system: values <1. The FIB-4 Index is a blood-based diagnostic test that looks at underlying fibrosis that can be used as a measure to help determine NAFLD/NASH status. 5 kPa indicates cirrh Learn how to interpret FibroScan results, including CAP score and liver stiffness values, and understand what they mean for fatty liver and fibrosis diagnosis. How the ELF Score is calculated We would like to show you a description here but the site won’t allow us. 25 could mean you’re at a high risk for liver fibrosis. We would like to show you a description here but the site won’t allow us. Free application. A higher FIB-4 score indicates a greater likelihood of significant liver fibrosis, while a lower score suggests minimal or no fibrosis. . Background and aims: The enhanced liver fibrosis (ELF) score is a blood test that combines three markers linked to liver fibrosis. 0 if age ≥65 years): Low probability of advanced fibrosis with approximately 90% negative predictive value—repeat testing in 2-3 years 1, 2 Progressive pulmonary fibrosis (PPF) is defined as interstitial lung disease (ILD) characterized by worsening respiratory symptoms, lung function decline, and continuing fibrosis. Download myFibroScan, your everyday FibroScan® companion to access the Interpretation Guide for FibroScan® results (LSM by VCTE™+ CAP™) and Scores FibroScan® based. 0 kPa indicates significant fibrosis (≥F2) and >12. Please note that the ranges of fibrosis results in the table are estimates. Normal: This means your liver has no scarring, or mild scarring. “ Fibrosis Score ” is a non-invasive estimate of liver scarring using routine blood tests. How is fibrosis scored? There are several scoring systems for evaluating chronic hepatitis, and they all include 2 components: inflammatory activity and degree of fibrosis. FibroScan staging – understanding a FibroScan result FibroScan® staging – understanding a FibroScan® result The FibroScan® provides a numerical score of liver stifness, which indicates the severity of liver fibrosis. Find out how it’s created. A lower kPa value suggests less scarring, indicating a healthier liver. Other methods for assessing liver fibrosis, including liver biopsy, magnetic resonance elastography, and serologic testing, are discussed separately. The most advanced stage of fibrosis is cirrhosis. 67 suggests advanced liver fibrosis. 0 kPa to exclude clinically significant fibrosis and a high cutoff of 12. If the person is at high risk of advanced liver fibrosis, refer to a hepatology specialist for further assessment and management. Please update your links and bookmarks. Fibrosis-4 (FIB-4) Calculator Share The Fibrosis-4 score helps to estimate the amount of scarring in the liver. 0 was more specific (91%) but less sensitive (46%). 7–10 ELF is included as a We would like to show you a description here but the site won’t allow us. If fibrosis is left untreated, it can lead to cirrhosis and liver cancer. Download scientific diagram | Interpretation of APRI, NAFLD Fibrosis Score, BARD Score, and Fib-4 Index from publication: Noninvasive, Blood-Based Biomarkers as Screening Tools for Hepatic We would like to show you a description here but the site won’t allow us. 51 suggests advanced liver fibrosis and is an indication for referral to a specialist in hepatology.

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